{"entity":{"id":"tox3","kind":"target","name":"TOX3","aka":["TOX high mobility group box family member 3","CAGF9","TNRC9"],"tldr":"TOX3 (TOX high mobility group box family member 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.72).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11972","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11972"},{"label":"UniProt O15405","url":"https://www.uniprot.org/uniprotkb/O15405/entry"},{"label":"NCBI Gene 27324","url":"https://www.ncbi.nlm.nih.gov/gene/27324"},{"label":"Ensembl ENSG00000103460","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103460"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TOX3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11972","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11972","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15405","url":"https://www.uniprot.org/uniprotkb/O15405/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000103460","url":"https://platform.opentargets.org/target/ENSG00000103460/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: breast cancer 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:11972","ensembl":"ENSG00000103460","uniprot":"O15405","entrez":"27324","biology":"Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the oestrogen-responsive or BCL-2 promoters. Required for depolarisation-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the oestrogen-responsive C3 promoter region. Location: Nucleus (UniProt). Locus 16q12.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tox3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}