{"entity":{"id":"tp63","kind":"target","name":"TP63","aka":["tumor protein p63","Tumor protein 63","p51","SHFM4","EEC3","p63","p73L","OFC8","p73H","p53CP","p40","TP73L","TP53L","TP53CP"],"tldr":"TP63 (Tumour protein 63) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Skin cancer, Non-Hodgkin lymphoma and 5 more.","summary":"Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription.\n\nOpen Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes affected pathway 0.40, literature 0.98, genetic association 0.72, somatic mutation 0.83, animal model 0.75). IntOGen calls it a driver in 5 cohorts (1 activating, 4 loss-of-function), covering Bladder Urothelial Carcinoma, Cervical Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Melanoma, Neuroblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15979","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15979"},{"label":"UniProt Q9H3D4","url":"https://www.uniprot.org/uniprotkb/Q9H3D4/entry"},{"label":"NCBI Gene 8626","url":"https://www.ncbi.nlm.nih.gov/gene/8626"},{"label":"Ensembl ENSG00000073282","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073282"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","skin-cancer","non-hodgkin-lymphoma","leukaemia","urothelial","cervical","head-and-neck","breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TP63","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:15979","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15979","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H3D4","url":"https://www.uniprot.org/uniprotkb/Q9H3D4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000073282","url":"https://platform.opentargets.org/target/ENSG00000073282/associations","note":"association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.63, melanoma 0.60, non-Hodgkin lymphoma 0.64, skin cancer 0.68, basal cell carcinoma 0.52, breast cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen TP63","url":"https://www.intogen.org/search?gene=TP63","note":"driver in 5 cohorts (Act 1, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:15979","ensembl":"ENSG00000073282","uniprot":"Q9H3D4","entrez":"8626","biology":"Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signalling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. Location: Nucleus (UniProt). Locus 3q28 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.69 with lung cancer (MONDO_0008903)","Skin cancer: Open Targets association 0.68 with skin cancer (MONDO_0002898)","Non-Hodgkin lymphoma: Open Targets association 0.64 with non-Hodgkin lymphoma (MONDO_0018908)","Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Cervical cancer: IntOGen driver in 1 cohort (CESC)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/tp63/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}