{"entity":{"id":"tph2","kind":"target","name":"TPH2","aka":["tryptophan hydroxylase 2","Tryptophan 5-hydroxylase 2","FLJ37295"],"tldr":"TPH2 (Tryptophan 5-hydroxylase 2) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.","summary":"Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates. Plays a crucial role in regulating mood, anxiety and sleep.\n\n","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20692","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20692"},{"label":"UniProt Q8IWU9","url":"https://www.uniprot.org/uniprotkb/Q8IWU9/entry"},{"label":"NCBI Gene 121278","url":"https://www.ncbi.nlm.nih.gov/gene/121278"},{"label":"Ensembl ENSG00000139287","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139287"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TPH2","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:20692","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20692","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IWU9","url":"https://www.uniprot.org/uniprotkb/Q8IWU9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000139287","url":"https://platform.opentargets.org/target/ENSG00000139287/associations","note":"per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:20692","ensembl":"ENSG00000139287","uniprot":"Q8IWU9","entrez":"121278","biology":"Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates. Plays a crucial role in regulating mood, anxiety and sleep. Locus 12q21.1 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.53 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/tph2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}