{"entity":{"id":"tpm3","kind":"target","name":"TPM3","aka":["tropomyosin 3","Tropomyosin alpha-3 chain","NEM1"],"tldr":"TPM3 (Tropomyosin alpha-3 chain) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer, Colorectal cancer and Non-small-cell lung cancer.","summary":"Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon.\n\nOpen Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.76, genetic association 0.09, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12012","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12012"},{"label":"UniProt P06753","url":"https://www.uniprot.org/uniprotkb/P06753/entry"},{"label":"NCBI Gene 7170","url":"https://www.ncbi.nlm.nih.gov/gene/7170"},{"label":"Ensembl ENSG00000143549","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143549"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer","colorectal","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TPM3","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12012","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12012","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P06753","url":"https://www.uniprot.org/uniprotkb/P06753/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000143549","url":"https://platform.opentargets.org/target/ENSG00000143549/associations","note":"association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.50, colorectal cancer 0.50, lung cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:12012","ensembl":"ENSG00000143549","uniprot":"P06753","entrez":"7170","biology":"Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1q21.3 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)","Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)","Non-small-cell lung cancer: Open Targets association 0.50 with non-small cell lung carcinoma (MONDO_0005233)"],"targetClass":"other","prevalence":[]},"route":"/targets/tpm3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}