{"entity":{"id":"tpm4","kind":"target","name":"TPM4","aka":["tropomyosin 4","Tropomyosin alpha-4 chain"],"tldr":"TPM4 (Tropomyosin alpha-4 chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.96, genetic association 0.19, somatic mutation 0.80, animal model 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12013","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12013"},{"label":"UniProt P67936","url":"https://www.uniprot.org/uniprotkb/P67936/entry"},{"label":"NCBI Gene 7171","url":"https://www.ncbi.nlm.nih.gov/gene/7171"},{"label":"Ensembl ENSG00000167460","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167460"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TPM4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12013","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12013","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P67936","url":"https://www.uniprot.org/uniprotkb/P67936/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000167460","url":"https://platform.opentargets.org/target/ENSG00000167460/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:12013","ensembl":"ENSG00000167460","uniprot":"P67936","entrez":"7171","biology":"Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilising cytoskeleton actin filaments. Binds calcium. Plays a role in platelet biogenesis. Location: Cytoplasm, cytoskeleton (UniProt). Locus 19p13.12-p13.11 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/tpm4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}