{"entity":{"id":"tpr","kind":"target","name":"TPR","aka":["translocated promoter region, nuclear basket protein","Nucleoprotein TPR"],"tldr":"TPR (Nucleoprotein TPR) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma and Medulloblastoma.","summary":"Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalisation in interphase, and in the mitotic spindle checkpoint signalling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.76, genetic association 0.04, somatic mutation 0.80). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Hepatocellular Carcinoma, Medulloblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12017","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12017"},{"label":"UniProt P12270","url":"https://www.uniprot.org/uniprotkb/P12270/entry"},{"label":"NCBI Gene 7175","url":"https://www.ncbi.nlm.nih.gov/gene/7175"},{"label":"Ensembl ENSG00000047410","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000047410"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TPR","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:12017","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12017","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P12270","url":"https://www.uniprot.org/uniprotkb/P12270/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000047410","url":"https://platform.opentargets.org/target/ENSG00000047410/associations","note":"association with cancer (MONDO_0004992) 0.71;  (GraphQL API, CC0)"},{"label":"IntOGen TPR","url":"https://www.intogen.org/search?gene=TPR","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:12017","ensembl":"ENSG00000047410","uniprot":"P12270","entrez":"7175","biology":"Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalisation in interphase, and in the mitotic spindle checkpoint signalling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Location: Nucleus; Nucleus membrane; Nucleus envelope; Nucleus, nuclear pore complex (UniProt). Locus 1q31.1 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Medulloblastoma: IntOGen driver in 1 cohort (MBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/tpr/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}]}}