{"entity":{"id":"tpt1","kind":"target","name":"TPT1","aka":["tumor protein, translationally-controlled 1","Translationally-controlled tumor protein","fortilin"],"tldr":"TPT1 (Translationally-controlled tumour protein) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.","summary":"Involved in calcium binding and microtubule stabilisation. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilisation of TSC22D1 protein.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sertraline.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12022","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12022"},{"label":"UniProt P13693","url":"https://www.uniprot.org/uniprotkb/P13693/entry"},{"label":"NCBI Gene 7178","url":"https://www.ncbi.nlm.nih.gov/gene/7178"},{"label":"Ensembl ENSG00000133112","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000133112"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TPT1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12022","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12022","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P13693","url":"https://www.uniprot.org/uniprotkb/P13693/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TPT1","url":"https://civicdb.org/features/5870","note":"1 evidence items, 0 assertions, 1 variants; diseases: Melanoma (GraphQL API, CC0)"}],"hgnc":"HGNC:12022","ensembl":"ENSG00000133112","uniprot":"P13693","entrez":"7178","biology":"Involved in calcium binding and microtubule stabilisation. Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilisation of TSC22D1 protein. Location: Cytoplasm (UniProt). Locus 13q14.13 (HGNC).","whereFound":["Melanoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/tpt1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}