{"entity":{"id":"traf7","kind":"target","name":"TRAF7","aka":["TNF receptor associated factor 7","E3 ubiquitin-protein ligase TRAF7","RNF119","DKFZp586I021","MGC7807","RFWD1"],"tldr":"TRAF7 (E3 ubiquitin-protein ligase TRAF7) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Skin cancer, Pleural mesothelioma and 1 more.","summary":"E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis. Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators. Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.83, animal model 0.60, genetic association 0.00, somatic mutation 0.96). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20456","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20456"},{"label":"UniProt Q6Q0C0","url":"https://www.uniprot.org/uniprotkb/Q6Q0C0/entry"},{"label":"NCBI Gene 84231","url":"https://www.ncbi.nlm.nih.gov/gene/84231"},{"label":"Ensembl ENSG00000131653","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131653"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["mesothelioma","skin-cancer","pleural-mesothelioma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRAF7","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:20456","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20456","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6Q0C0","url":"https://www.uniprot.org/uniprotkb/Q6Q0C0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000131653","url":"https://platform.opentargets.org/target/ENSG00000131653/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.52, skin cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen TRAF7","url":"https://www.intogen.org/search?gene=TRAF7","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:20456","ensembl":"ENSG00000131653","uniprot":"Q6Q0C0","entrez":"84231","biology":"E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis. Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators. Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response. Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B. Location: Cytoplasmic vesicle; Cytoplasm; Nucleus (UniProt). Locus 16p13.3 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 2 cohorts (PLMESO)","Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)","Pleural mesothelioma: IntOGen driver in 2 cohorts (PLMESO)","Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/traf7/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}