{"entity":{"id":"trak1","kind":"target","name":"TRAK1","aka":["trafficking kinesin protein 1","Trafficking kinesin-binding protein 1","OIP106","KIAA1042","MILT1"],"tldr":"TRAK1 (Trafficking kinesin-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.39, affected pathway 0.89, animal model 0.36, genetic association 0.32).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29947","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29947"},{"label":"UniProt Q9UPV9","url":"https://www.uniprot.org/uniprotkb/Q9UPV9/entry"},{"label":"NCBI Gene 22906","url":"https://www.ncbi.nlm.nih.gov/gene/22906"},{"label":"Ensembl ENSG00000182606","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182606"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRAK1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:29947","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29947","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UPV9","url":"https://www.uniprot.org/uniprotkb/Q9UPV9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000182606","url":"https://platform.opentargets.org/target/ENSG00000182606/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:29947","ensembl":"ENSG00000182606","uniprot":"Q9UPV9","entrez":"22906","biology":"Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. Location: Cytoplasm; Nucleus; Mitochondrion; Early endosome (UniProt). Locus 3p22.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/trak1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}