{"entity":{"id":"trim24","kind":"target","name":"TRIM24","aka":["tripartite motif containing 24","Transcription intermediary factor 1-alpha","hTIF1","Tif1a","RNF82","TIF1A","TIF1"],"tldr":"TRIM24 (Transcription intermediary factor 1-alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Prostate cancer, Lung cancer and 3 more.","summary":"Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity.\n\nOpen Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes affected pathway 0.96, literature 0.98, genetic association 0.44, somatic mutation 0.83, animal model 0.71). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11812","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11812"},{"label":"UniProt O15164","url":"https://www.uniprot.org/uniprotkb/O15164/entry"},{"label":"NCBI Gene 8805","url":"https://www.ncbi.nlm.nih.gov/gene/8805"},{"label":"Ensembl ENSG00000122779","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122779"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["leukaemia","prostate","lung-cancer","breast-cancer","ovarian","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRIM24","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11812","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11812","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15164","url":"https://www.uniprot.org/uniprotkb/O15164/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000122779","url":"https://platform.opentargets.org/target/ENSG00000122779/associations","note":"association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: ovarian cancer 0.51, non-Hodgkin lymphoma 0.51, breast cancer 0.53, lung cancer 0.53, leukaemia 0.60 (GraphQL API, CC0)"},{"label":"IntOGen TRIM24","url":"https://www.intogen.org/search?gene=TRIM24","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11812","ensembl":"ENSG00000122779","uniprot":"O15164","entrez":"8805","biology":"Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation. Location: Nucleus; Cytoplasm; Mitochondrion (UniProt). Locus 7q33-q34 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)","Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/trim24/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}