{"entity":{"id":"trim27","kind":"target","name":"TRIM27","aka":["tripartite motif containing 27","Zinc finger protein RFP","RNF76"],"tldr":"TRIM27 (Zinc finger protein RFP) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy. Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9975","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9975"},{"label":"UniProt P14373","url":"https://www.uniprot.org/uniprotkb/P14373/entry"},{"label":"NCBI Gene 5987","url":"https://www.ncbi.nlm.nih.gov/gene/5987"},{"label":"Ensembl ENSG00000204713","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204713"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRIM27","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:9975","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9975","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P14373","url":"https://www.uniprot.org/uniprotkb/P14373/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000204713","url":"https://platform.opentargets.org/target/ENSG00000204713/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:9975","ensembl":"ENSG00000204713","uniprot":"P14373","entrez":"5987","biology":"E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy. Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Location: Nucleus; Cytoplasm; Nucleus, PML body; Early endosome (UniProt). Locus 6p22.1 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/trim27/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}