{"entity":{"id":"trim33","kind":"target","name":"TRIM33","aka":["tripartite motif containing 33","E3 ubiquitin-protein ligase TRIM33","TIF1GAMMA","FLJ11429","KIAA1113","TIFGAMMA","RFG7","TF1G","TIF1G","PTC7"],"tldr":"TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.","summary":"Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, animal model 0.41, genetic association 0.02, somatic mutation 0.98). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16290","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16290"},{"label":"UniProt Q9UPN9","url":"https://www.uniprot.org/uniprotkb/Q9UPN9/entry"},{"label":"NCBI Gene 51592","url":"https://www.ncbi.nlm.nih.gov/gene/51592"},{"label":"Ensembl ENSG00000197323","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197323"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","breast-cancer","colorectal","medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRIM33","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:16290","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16290","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UPN9","url":"https://www.uniprot.org/uniprotkb/Q9UPN9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000197323","url":"https://platform.opentargets.org/target/ENSG00000197323/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: colorectal cancer 0.50, breast cancer 0.53, lung cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen TRIM33","url":"https://www.intogen.org/search?gene=TRIM33","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:16290","ensembl":"ENSG00000197323","uniprot":"Q9UPN9","entrez":"51592","biology":"Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signalling cascade. Plays a role in the control of cell proliferation. Location: Nucleus (UniProt). Locus 1p13.2 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)","Medulloblastoma: IntOGen driver in 2 cohorts (MBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/trim33/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"}]}}