{"entity":{"id":"trim49c","kind":"target","name":"TRIM49C","aka":["tripartite motif containing 49C","Tripartite motif-containing protein 49C","TRIM49L2"],"tldr":"TRIM49C (Tripartite motif-containing protein 49C) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.","summary":"UniProt has no function text for P0CI26; HGNC names it \"tripartite motif containing 49C\".\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Stomach Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:38877","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:38877"},{"label":"UniProt P0CI26","url":"https://www.uniprot.org/uniprotkb/P0CI26/entry"},{"label":"NCBI Gene 642612","url":"https://www.ncbi.nlm.nih.gov/gene/642612"},{"label":"Ensembl ENSG00000204449","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204449"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRIM49C","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:38877","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:38877","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P0CI26","url":"https://www.uniprot.org/uniprotkb/P0CI26/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TRIM49C","url":"https://www.intogen.org/search?gene=TRIM49C","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:38877","ensembl":"ENSG00000204449","uniprot":"P0CI26","entrez":"642612","biology":"UniProt has no function text for P0CI26; HGNC names it \"tripartite motif containing 49C\". Locus 11q14.3 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/trim49c/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}