{"entity":{"id":"trps1","kind":"target","name":"TRPS1","aka":["transcriptional repressor GATA binding 1","Zinc finger transcription factor Trps1","GC79"],"tldr":"TRPS1 (Zinc finger transcription factor Trps1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.25, animal model 0.57, genetic association 0.69).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12340","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12340"},{"label":"UniProt Q9UHF7","url":"https://www.uniprot.org/uniprotkb/Q9UHF7/entry"},{"label":"NCBI Gene 7227","url":"https://www.ncbi.nlm.nih.gov/gene/7227"},{"label":"Ensembl ENSG00000104447","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104447"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TRPS1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12340","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12340","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UHF7","url":"https://www.uniprot.org/uniprotkb/Q9UHF7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000104447","url":"https://platform.opentargets.org/target/ENSG00000104447/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: breast cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:12340","ensembl":"ENSG00000104447","uniprot":"Q9UHF7","entrez":"7227","biology":"Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Location: Nucleus (UniProt). Locus 8q23.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/trps1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}