{"entity":{"id":"tubb3","kind":"target","name":"TUBB3","aka":["tubulin beta 3 class III","Tubulin beta-3 chain","beta-4","CFEOM3","CFEOM3A","FEOM3"],"tldr":"TUBB3 (Tubulin beta-3 chain) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Prostate cancer and 5 more.","summary":"Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Paclitaxel and Taxane Compound. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes clinical 1.00, affected pathway 0.61, literature 0.95, genetic association 0.28, somatic mutation 0.23, animal model 0.36).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20772","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20772"},{"label":"UniProt Q13509","url":"https://www.uniprot.org/uniprotkb/Q13509/entry"},{"label":"NCBI Gene 10381","url":"https://www.ncbi.nlm.nih.gov/gene/10381"},{"label":"Ensembl ENSG00000258947","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000258947"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["breast-cancer","lung-cancer","prostate","non-hodgkin-lymphoma","hodgkin-lymphoma","sarcoma","cervical","multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 1.00; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TUBB3","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:20772","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20772","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13509","url":"https://www.uniprot.org/uniprotkb/Q13509/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene TUBB3","url":"https://civicdb.org/features/8262","note":"2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer, Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000258947","url":"https://platform.opentargets.org/target/ENSG00000258947/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, gastric cancer 0.55, prostate cancer 0.63, ovarian cancer 0.58, cervical cancer 0.59, head and neck squamous cell carcinoma 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:20772","ensembl":"ENSG00000258947","uniprot":"Q13509","entrez":"10381","biology":"Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerised TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. Location: Cytoplasm, cytoskeleton; Cell projection, growth cone; Cell projection, lamellipodium; Cell projection, filopodium (UniProt). Locus 16q24.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.63 with breast cancer (MONDO_0007254); CIViC evidence names this disease","Lung cancer: Open Targets association 0.63 with lung cancer (MONDO_0008903)","Prostate cancer: Open Targets association 0.63 with prostate cancer (MONDO_0008315)","Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)","Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952)","Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)"],"targetClass":"other","prevalence":[]},"route":"/targets/tubb3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}