{"entity":{"id":"tubb4b","kind":"target","name":"TUBB4B","aka":["tubulin beta 4B class IVb","Tubulin beta-4B chain","Beta2","TUBB2C"],"tldr":"TUBB4B (Tubulin beta-4B chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Breast cancer, Non-Hodgkin lymphoma and 5 more.","summary":"Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.54, affected pathway 0.25, genetic association 0.00, clinical 1.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:20771","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20771"},{"label":"UniProt P68371","url":"https://www.uniprot.org/uniprotkb/P68371/entry"},{"label":"NCBI Gene 10383","url":"https://www.ncbi.nlm.nih.gov/gene/10383"},{"label":"Ensembl ENSG00000188229","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188229"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer","breast-cancer","non-hodgkin-lymphoma","prostate","hodgkin-lymphoma","cervical","multiple-myeloma","sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 1.00. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TUBB4B","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:20771","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20771","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P68371","url":"https://www.uniprot.org/uniprotkb/P68371/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000188229","url":"https://platform.opentargets.org/target/ENSG00000188229/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, gastric cancer 0.57, prostate cancer 0.59, ovarian cancer 0.57, cervical cancer 0.58, head and neck squamous cell carcinoma 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:20771","ensembl":"ENSG00000188229","uniprot":"P68371","entrez":"10383","biology":"Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, flagellum axoneme (UniProt). Locus 9q34.3 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.62 with lung cancer (MONDO_0008903)","Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)","Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)","Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)","Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952)","Cervical cancer: Open Targets association 0.58 with cervical cancer (MONDO_0002974)"],"targetClass":"other","prevalence":[]},"route":"/targets/tubb4b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}