{"entity":{"id":"tyrp1","kind":"target","name":"TYRP1","aka":["tyrosinase related protein 1","5,6-dihydroxyindole-2-carboxylic acid oxidase","GP75","b-PROTEIN","OCA3","CAS2"],"tldr":"TYRP1 (5,6-dihydroxyindole-2-carboxylic acid oxidase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.","summary":"Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesised.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.56, animal model 0.63, genetic association 0.70).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12450","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12450"},{"label":"UniProt P17643","url":"https://www.uniprot.org/uniprotkb/P17643/entry"},{"label":"NCBI Gene 7306","url":"https://www.ncbi.nlm.nih.gov/gene/7306"},{"label":"Ensembl ENSG00000107165","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107165"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TYRP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12450","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12450","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P17643","url":"https://www.uniprot.org/uniprotkb/P17643/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000107165","url":"https://platform.opentargets.org/target/ENSG00000107165/associations","note":"association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: skin cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:12450","ensembl":"ENSG00000107165","uniprot":"P17643","entrez":"7306","biology":"Plays a role in melanin biosynthesis. Catalyses the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesised. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. Location: Melanosome membrane (UniProt). Locus 9p23 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/tyrp1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}