{"entity":{"id":"tyw2","kind":"target","name":"TYW2","aka":["tRNA wybutosine-synthesizing protein 2","tRNA wybutosine-synthesizing protein 2 homolog","FLJ20772","Trm12","TRMT12"],"tldr":"TYW2 (tRNA wybutosine-synthesising protein 2 homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers.","summary":"S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyses the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Salivary Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:26091","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26091"},{"label":"UniProt Q53H54","url":"https://www.uniprot.org/uniprotkb/Q53H54/entry"},{"label":"NCBI Gene 55039","url":"https://www.ncbi.nlm.nih.gov/gene/55039"},{"label":"Ensembl ENSG00000183665","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183665"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["salivary-gland"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"TYW2","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:26091","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26091","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q53H54","url":"https://www.uniprot.org/uniprotkb/Q53H54/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen TYW2","url":"https://www.intogen.org/search?gene=TYW2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:26091","ensembl":"ENSG00000183665","uniprot":"Q53H54","entrez":"55039","biology":"S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyses the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. Locus 8q24.13 (HGNC).","whereFound":["Salivary gland cancers: IntOGen driver in 1 cohort (SACA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/tyw2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"salivary-gland","kind":"cancer","name":"Salivary gland cancers","route":"/cancers/salivary-gland/"}]}}