{"entity":{"id":"uba52","kind":"target","name":"UBA52","aka":["ubiquitin A-52 residue ribosomal protein fusion product 1","Ubiquitin-ribosomal protein eL40 fusion protein","RPL40","CEP52","HUBCEP52","MGC57125","MGC126879","MGC126881","L40"],"tldr":"UBA52 (Ubiquitin-ribosomal protein eL40 fusion protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signalling processes leading to activation of the transcription factor NF-kappa-B.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.83, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12458","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12458"},{"label":"UniProt P62987","url":"https://www.uniprot.org/uniprotkb/P62987/entry"},{"label":"NCBI Gene 7311","url":"https://www.ncbi.nlm.nih.gov/gene/7311"},{"label":"Ensembl ENSG00000221983","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221983"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"UBA52","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12458","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12458","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62987","url":"https://www.uniprot.org/uniprotkb/P62987/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000221983","url":"https://platform.opentargets.org/target/ENSG00000221983/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:12458","ensembl":"ENSG00000221983","uniprot":"P62987","entrez":"7311","biology":"Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signalling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signalling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signalling. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.1-p12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/uba52/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}