{"entity":{"id":"ubxn11","kind":"target","name":"UBXN11","aka":["UBX domain protein 11","UBX domain-containing protein 11","UBXD5"],"tldr":"UBXN11 (UBX domain-containing protein 11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.","summary":"May be involved in the reorganisation of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30600","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30600"},{"label":"UniProt Q5T124","url":"https://www.uniprot.org/uniprotkb/Q5T124/entry"},{"label":"NCBI Gene 91544","url":"https://www.ncbi.nlm.nih.gov/gene/91544"},{"label":"Ensembl ENSG00000158062","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158062"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"UBXN11","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30600","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30600","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5T124","url":"https://www.uniprot.org/uniprotkb/Q5T124/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen UBXN11","url":"https://www.intogen.org/search?gene=UBXN11","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30600","ensembl":"ENSG00000158062","uniprot":"Q5T124","entrez":"91544","biology":"May be involved in the reorganisation of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1p36.11 (HGNC).","whereFound":["Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/ubxn11/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}]}}