{"entity":{"id":"ucl-proton-hemithoracic-mpm","kind":"trial","name":"Hemithoracic irradiation with proton therapy in malignant pleural mesothelioma (UCL)","aka":[],"tldr":"The trial asking whether proton beams can deliver radiotherapy to the whole lining of one side of the chest in mesothelioma without the collateral damage that has kept hemithoracic radiotherapy out of routine care.","summary":"Radiotherapy to the entire hemithorax has repeatedly failed to help mesothelioma patients because the dose needed hits the heart, the remaining lung and the liver. Proton therapy stops sharply at a set depth, so it can cover the pleural surface with far less dose behind it. This University College London study, registered as NCT05655078 and recruiting since March 2024 with 148 patients planned, tests hemithoracic proton beam therapy in malignant pleural mesothelioma. It is the only proton therapy trial in mesothelioma on the registry.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT05655078","url":"https://clinicaltrials.gov/study/NCT05655078"}],"tags":["owner-request"],"related":[],"cancers":["mesothelioma"],"sections":[],"technologies":["proton-therapy"],"targets":[],"drugs":[],"companies":[],"institutions":["uclh"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05655078","phase":"2","setting":"Malignant pleural mesothelioma; hemithoracic proton beam therapy to the whole pleural surface, a technique that protects the heart, opposite lung and liver better than photon radiotherapy; started March 2024, 148 planned","sponsor":"University College London","enrolled":148,"outcomes":[]},"route":"/trials/ucl-proton-hemithoracic-mpm/","neighbours":{"cancer":[{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"}],"technology":[{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"}],"institution":[{"id":"uclh","kind":"institution","name":"University College London Hospitals / UCL Cancer Institute","route":"/institutions/uclh/"}]}}