{"entity":{"id":"ugt1a","kind":"target","name":"UGT1A","aka":["UDP glucuronosyltransferase family 1 member A complex locus","UGT1A@"],"tldr":"UGT1A (UDP glucuronosyltransferase family 1 member A complex locus) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.","summary":"UniProt has no function text for this gene; HGNC names it \"UDP glucuronosyltransferase family 1 member A complex locus\".\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Ganetespib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12529","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12529"},{"label":"NCBI Gene 7361","url":"https://www.ncbi.nlm.nih.gov/gene/7361"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"UGT1A","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12529","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12529","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"CIViC gene UGT1A","url":"https://civicdb.org/features/6023","note":"1 evidence items, 0 assertions, 2 variants; diseases: Colorectal Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:12529","entrez":"7361","biology":"UniProt has no function text for this gene; HGNC names it \"UDP glucuronosyltransferase family 1 member A complex locus\". Locus 2q37 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ugt1a/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}