{"entity":{"id":"urea-cream","kind":"drug","name":"Urea cream","aka":["urea-based cream","10% urea cream"],"tldr":"Urea cream softens thick, dry skin. Rubbed on the hands and feet from the first day of sorafenib, a 10 per cent cream made the painful hand-foot skin reaction less common in a large trial.","summary":"A DailyMed listing for a 40% urea cream describes use for debridement of hyperkeratotic lesions and for hyperkeratotic conditions such as dry rough skin, eczema, keratoderma, corns and calluses; that listing carries no FDA application number. In a randomised open-label trial in 871 people with advanced hepatocellular carcinoma starting sorafenib (Ren et al., J Clin Oncol 2015), 10% urea-based cream three times a day from day 1 with best supportive care lowered the 12-week incidence of any-grade hand-foot skin reaction compared with best supportive care alone (56.0% vs 73.6%; odds ratio 0.457, 95% CI 0.344 to 0.608); the authors called for blinded placebo-controlled trials.","status":"established","asOf":"2026-11-11","wikipedia":"https://en.wikipedia.org/wiki/Urea","links":[{"label":"US label (DailyMed): urea cream 40% (listing)","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0920f780-b504-1fea-e063-6394a90ae5a9"},{"label":"Ren et al., Randomized controlled trial of the prophylactic effect of urea-based cream on sorafenib-associated hand-foot skin reactions in advanced hepatocellular carcinoma (J Clin Oncol 2015)","url":"https://doi.org/10.1200/JCO.2013.52.9651"}],"tags":["supportive","generic","supportive-care-gaps-2026-11"],"related":["sorafenib"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["hand-foot-syndrome"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo supportive care gap fill (DailyMed, openFDA, Drugs@FDA, emc SmPCs, NICE, ESMO, ASCO, MASCC, SITC, ASTCT, ITAC, Europe PMC)","editedOn":"2026-11-11"},"modality":"Topical keratolytic emollient","supportive":true,"mechanism":"Urea softens and moisturises thickened skin and helps shed hard surface layers.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/urea-cream/","neighbours":{"drug":[{"id":"sorafenib","kind":"drug","name":"Sorafenib","route":"/drugs/sorafenib/"}],"term":[{"id":"hand-foot-syndrome","kind":"term","name":"Hand-foot syndrome and hand-foot skin reaction","route":"/terms/hand-foot-syndrome/"}]}}