{"entity":{"id":"urgent-help-tnbc","kind":"term","name":"When to seek urgent help with triple-negative breast cancer (NHS 111 and 999)","aka":[],"tldr":"Call 999 for signs of sepsis, sudden severe breathlessness, a seizure or new confusion; ring the hospital's 24-hour line straight away for a temperature over 37.5 C or below 36 C, for diarrhoea that meets your drug's threshold, for a new cough or breathlessness on pembrolizumab or a deruxtecan drug, or for yellow eyes; use NHS 111 when you cannot reach the team and are not sure.","summary":"The wording, situation by situation. Sepsis (999 or A&E, NHS): breathing very fast; confused, slurred speech or not making sense; blue, pale or blotchy skin; a very high or very low temperature, feeling hot or cold to the touch, or shivery; a rash that does not fade when pressed. Infection on chemotherapy (24-hour line, Macmillan): temperature over 37.5 C or below 36 C, shivering, feeling unwell even with a normal temperature. Immune-related reactions on pembrolizumab (24-hour line, Macmillan): more stools than usual or stools at night, tummy cramps; breathlessness, a cough that does not go away, wheeze or fever; yellow skin or eyes; unusual tiredness, headaches, dizziness, thirst. Lung inflammation on trastuzumab deruxtecan or datopotamab deruxtecan (24-hour line): any new cough, breathlessness or fever. Brain symptoms (999): a seizure, sudden severe headache, new weakness or confusion. The NHS says use 111 online or call 111 when you think you need medical help right now and it is not an emergency. This is orientation from public patient pages and guidelines, not advice for your case: your own team's instructions and 24-hour number come first.","asOf":"2026-09-24","links":[{"label":"NHS: sepsis","url":"https://www.nhs.uk/conditions/sepsis/"},{"label":"Macmillan: sepsis","url":"https://www.macmillan.org.uk/cancer-information-and-support/impacts-of-cancer/sepsis"},{"label":"Macmillan: pembrolizumab","url":"https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/pembrolizumab"},{"label":"NHS: when to use 111","url":"https://www.nhs.uk/nhs-services/urgent-and-emergency-care-services/when-to-use-111/"},{"label":"NHS: when to call 999","url":"https://www.nhs.uk/nhs-services/urgent-and-emergency-care-services/when-to-call-999/"}],"tags":[],"related":[],"cancers":["tnbc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["febrile-neutropenia","irae","ild","immune-colitis"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical"},"route":"/terms/urgent-help-tnbc/","neighbours":{"cancer":[{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"term":[{"id":"febrile-neutropenia","kind":"term","name":"Febrile neutropenia","route":"/terms/febrile-neutropenia/"},{"id":"immune-colitis","kind":"term","name":"Immune-mediated colitis and diarrhoea","route":"/terms/immune-colitis/"},{"id":"irae","kind":"term","name":"Immune-related adverse events (irAEs)","route":"/terms/irae/"},{"id":"ild","kind":"term","name":"Interstitial lung disease (ILD) / pneumonitis","route":"/terms/ild/"}]}}