{"entity":{"id":"usp8","kind":"target","name":"USP8","aka":["ubiquitin specific peptidase 8","Ubiquitin carboxyl-terminal hydrolase 8","HumORF8","KIAA0055","SPG59"],"tldr":"USP8 (Ubiquitin carboxyl-terminal hydrolase 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Breast cancer and 1 more.","summary":"Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12631","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12631"},{"label":"UniProt P40818","url":"https://www.uniprot.org/uniprotkb/P40818/entry"},{"label":"NCBI Gene 9101","url":"https://www.ncbi.nlm.nih.gov/gene/9101"},{"label":"Ensembl ENSG00000138592","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138592"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","multiple-myeloma","breast-cancer","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"USP8","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:12631","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12631","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P40818","url":"https://www.uniprot.org/uniprotkb/P40818/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138592","url":"https://platform.opentargets.org/target/ENSG00000138592/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: breast cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen USP8","url":"https://www.intogen.org/search?gene=USP8","note":"driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:12631","ensembl":"ENSG00000138592","uniprot":"P40818","entrez":"9101","biology":"Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Location: Cytoplasm; Nucleus; Endosome membrane; Cell membrane (UniProt). Locus 15q21.2 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/usp8/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}