{"entity":{"id":"vav1","kind":"target","name":"VAV1","aka":["vav guanine nucleotide exchange factor 1","Proto-oncogene vav"],"tldr":"VAV1 (Proto-oncogene vav) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.","summary":"Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12657","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12657"},{"label":"UniProt P15498","url":"https://www.uniprot.org/uniprotkb/P15498/entry"},{"label":"NCBI Gene 7409","url":"https://www.ncbi.nlm.nih.gov/gene/7409"},{"label":"Ensembl ENSG00000141968","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141968"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"VAV1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:12657","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12657","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15498","url":"https://www.uniprot.org/uniprotkb/P15498/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen VAV1","url":"https://www.intogen.org/search?gene=VAV1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:12657","ensembl":"ENSG00000141968","uniprot":"P15498","entrez":"7409","biology":"Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. Locus 19p13.3 (HGNC).","whereFound":["Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/vav1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}