{"entity":{"id":"vcl","kind":"target","name":"VCL","aka":["vinculin","Vinculin"],"tldr":"VCL (Vinculin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12665","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12665"},{"label":"UniProt P18206","url":"https://www.uniprot.org/uniprotkb/P18206/entry"},{"label":"NCBI Gene 7414","url":"https://www.ncbi.nlm.nih.gov/gene/7414"},{"label":"Ensembl ENSG00000035403","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000035403"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"VCL","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12665","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12665","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P18206","url":"https://www.uniprot.org/uniprotkb/P18206/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000035403","url":"https://platform.opentargets.org/target/ENSG00000035403/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:12665","ensembl":"ENSG00000035403","uniprot":"P18206","entrez":"7414","biology":"Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Location: Cell membrane; Cell junction, adherens junction; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10q22.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/vcl/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}