{"entity":{"id":"vls-1488","kind":"drug","name":"VLS-1488","aka":[],"tldr":"VLS-1488 is an experimental pill from Volastra Therapeutics, in phase 1 trials for high-grade serous ovarian cancer and other cancers with unstable chromosomes.","summary":"VLS-1488 is a small molecule, oral from Volastra Therapeutics. Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide. Its phase 1/2 study (NCT05902988) recruits people with high-grade serous ovarian cancer, squamous non-small cell lung cancer, triple-negative breast cancer, head and neck squamous cell carcinoma and uterine cancers. The company reports an FDA Fast Track designation in platinum-resistant high-grade serous ovarian cancer. Whether it works in people has not been established.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"Volastra Therapeutics pipeline","url":"https://www.volastratx.com/pipeline/"},{"label":"ClinicalTrials.gov NCT05902988","url":"https://clinicaltrials.gov/study/NCT05902988"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["high-grade-serous-ovarian-cancer","tnbc","head-and-neck"],"sections":[],"technologies":[],"targets":["kif18a"],"drugs":[],"companies":["volastra-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct05902988"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors, investor portfolios (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-04"},"code":"VLS-1488","modality":"Small molecule, oral","mechanism":"Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/vls-1488/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"high-grade-serous-ovarian-cancer","kind":"cancer","name":"High-grade serous ovarian cancer","route":"/cancers/high-grade-serous-ovarian-cancer/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"target":[{"id":"kif18a","kind":"target","name":"KIF18A","route":"/targets/kif18a/"}],"company":[{"id":"volastra-therapeutics","kind":"company","name":"Volastra Therapeutics","route":"/companies/volastra-therapeutics/"}],"trial":[{"id":"nct05902988","kind":"trial","name":"A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer","route":"/trials/nct05902988/"}]}}