{"entity":{"id":"vps53","kind":"target","name":"VPS53","aka":["VPS53 subunit of GARP complex","Vacuolar protein sorting-associated protein 53 homolog","FLJ10979","HCCS1"],"tldr":"VPS53 (Vacuolar protein sorting-associated protein 53 homolog) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, genetic association 0.69).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25608","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25608"},{"label":"UniProt Q5VIR6","url":"https://www.uniprot.org/uniprotkb/Q5VIR6/entry"},{"label":"NCBI Gene 55275","url":"https://www.ncbi.nlm.nih.gov/gene/55275"},{"label":"Ensembl ENSG00000141252","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141252"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"VPS53","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:25608","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25608","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5VIR6","url":"https://www.uniprot.org/uniprotkb/Q5VIR6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000141252","url":"https://platform.opentargets.org/target/ENSG00000141252/associations","note":"association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: prostate cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:25608","ensembl":"ENSG00000141252","uniprot":"Q5VIR6","entrez":"55275","biology":"Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalised transferrin receptor (TFRC) to the plasma membrane. Location: Golgi apparatus, trans-Golgi network membrane; Endosome membrane; Recycling endosome (UniProt). Locus 17p13.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.53 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/vps53/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}