{"entity":{"id":"vwf","kind":"target","name":"VWF","aka":["von Willebrand factor","F8VWF"],"tldr":"VWF (von Willebrand factor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.97, animal model 0.53, genetic association 0.31).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12726","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12726"},{"label":"UniProt P04275","url":"https://www.uniprot.org/uniprotkb/P04275/entry"},{"label":"NCBI Gene 7450","url":"https://www.ncbi.nlm.nih.gov/gene/7450"},{"label":"Ensembl ENSG00000110799","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110799"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"VWF","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12726","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12726","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P04275","url":"https://www.uniprot.org/uniprotkb/P04275/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000110799","url":"https://platform.opentargets.org/target/ENSG00000110799/associations","note":"association with cancer (MONDO_0004992) 0.66;  (GraphQL API, CC0)"}],"hgnc":"HGNC:12726","ensembl":"ENSG00000110799","uniprot":"P04275","entrez":"7450","biology":"Important in the maintenance of haemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilising its heterodimeric structure and protecting it from premature clearance from plasma. Location: Secreted; Secreted, extracellular space, extracellular matrix (UniProt). Locus 12p13.31 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/vwf/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}