{"entity":{"id":"wdr12","kind":"target","name":"WDR12","aka":["WD repeat domain 12","Ribosome biogenesis protein WDR12","YTM1","FLJ10881"],"tldr":"WDR12 (Ribosome biogenesis protein WDR12) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.","summary":"Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14098","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14098"},{"label":"UniProt Q9GZL7","url":"https://www.uniprot.org/uniprotkb/Q9GZL7/entry"},{"label":"NCBI Gene 55759","url":"https://www.ncbi.nlm.nih.gov/gene/55759"},{"label":"Ensembl ENSG00000138442","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138442"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WDR12","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:14098","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14098","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9GZL7","url":"https://www.uniprot.org/uniprotkb/Q9GZL7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene WDR12","url":"https://civicdb.org/features/13185","note":"1 evidence items, 0 assertions, 1 variants; diseases: Glioblastoma (GraphQL API, CC0)"}],"hgnc":"HGNC:14098","ensembl":"ENSG00000138442","uniprot":"Q9GZL7","entrez":"55759","biology":"Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Location: Nucleus, nucleolus; Nucleus, nucleoplasm (UniProt). Locus 2q33.2 (HGNC).","whereFound":["Glioma & glioblastoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/wdr12/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}]}}