{"entity":{"id":"wif1","kind":"target","name":"WIF1","aka":["Wnt inhibitory factor 1"],"tldr":"WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.","summary":"Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.19, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18081","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18081"},{"label":"UniProt Q9Y5W5","url":"https://www.uniprot.org/uniprotkb/Q9Y5W5/entry"},{"label":"NCBI Gene 11197","url":"https://www.ncbi.nlm.nih.gov/gene/11197"},{"label":"Ensembl ENSG00000156076","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156076"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WIF1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18081","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18081","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y5W5","url":"https://www.uniprot.org/uniprotkb/Q9Y5W5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156076","url":"https://platform.opentargets.org/target/ENSG00000156076/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: breast cancer 0.55, oral cavity cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:18081","ensembl":"ENSG00000156076","uniprot":"Q9Y5W5","entrez":"11197","biology":"Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Location: Secreted (UniProt). Locus 12q14.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)"],"targetClass":"other","prevalence":[]},"route":"/targets/wif1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"}]}}