{"entity":{"id":"wnt1","kind":"target","name":"WNT1","aka":["Wnt family member 1","Proto-oncogene Wnt-1","INT1"],"tldr":"WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.","summary":"Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12774","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12774"},{"label":"UniProt P04628","url":"https://www.uniprot.org/uniprotkb/P04628/entry"},{"label":"NCBI Gene 7471","url":"https://www.ncbi.nlm.nih.gov/gene/7471"},{"label":"Ensembl ENSG00000125084","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125084"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["uterine-carcinosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WNT1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:12774","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12774","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P04628","url":"https://www.uniprot.org/uniprotkb/P04628/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen WNT1","url":"https://www.intogen.org/search?gene=WNT1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:12774","ensembl":"ENSG00000125084","uniprot":"P04628","entrez":"7471","biology":"Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 12q13.12 (HGNC).","whereFound":["Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/wnt1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"uterine-carcinosarcoma","kind":"cancer","name":"Uterine carcinosarcoma","route":"/cancers/uterine-carcinosarcoma/"}]}}