{"entity":{"id":"wt1","kind":"target","name":"WT1","aka":["WT1 transcription factor","Wilms tumor protein","WIT-2","AWT1","NPHS4","WT-1"],"tldr":"WT1 (Wilms tumour protein) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Mesothelioma, Myeloproliferative neoplasms and 5 more.","summary":"Transcription factor that plays an important role in cellular development and cell survival. Recognises and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO.\n\nCIViC holds 12 clinical evidence items and 0 assertions across 3 variants, naming Daunorubicin and Cytarabine. Open Targets scores its association with cancer at 0.90 (direct and indirect evidence; datatypes clinical 0.63, genetic literature 0.90, affected pathway 0.36, literature 1.00, genetic association 0.91, somatic mutation 0.89, animal model 0.68). IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Acute Myeloid Leukaemia, Melanoma, Pancreatic Adenocarcinoma. In OnCo, 1 product record names it (INO-5401).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12796","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12796"},{"label":"UniProt P19544","url":"https://www.uniprot.org/uniprotkb/P19544/entry"},{"label":"NCBI Gene 7490","url":"https://www.ncbi.nlm.nih.gov/gene/7490"},{"label":"Ensembl ENSG00000184937","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184937"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["leukaemia","mesothelioma","myeloproliferative-neoplasms","non-hodgkin-lymphoma","sarcoma","pancreatic","wilms-tumor","aml"],"sections":[],"technologies":[],"targets":[],"drugs":["ino-5401"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.63; IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts; CIViC holds 12 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WT1","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12796","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12796","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P19544","url":"https://www.uniprot.org/uniprotkb/P19544/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene WT1","url":"https://civicdb.org/features/49","note":"12 evidence items, 0 assertions, 3 variants; diseases: Acute Myeloid Leukaemia (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000184937","url":"https://platform.opentargets.org/target/ENSG00000184937/associations","note":"association with cancer (MONDO_0004992) 0.90; per-cancer scores at or above 0.5: sarcoma 0.59, malignant mesothelioma 0.69, acute myeloid leukaemia 0.65, acute lymphoblastic leukaemia 0.56, non-Hodgkin lymphoma 0.60, myeloproliferative neoplasm 0.68 (GraphQL API, CC0)"},{"label":"IntOGen WT1","url":"https://www.intogen.org/search?gene=WT1","note":"driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:12796","ensembl":"ENSG00000184937","uniprot":"P19544","entrez":"7490","biology":"Transcription factor that plays an important role in cellular development and cell survival. Recognises and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumour suppressor as well as an oncogenic role in tumour formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Location: Nucleus; Nucleus, nucleolus; Cytoplasm; Nucleus speckle (UniProt). Locus 11p13 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.72 with leukaemia (MONDO_0005059)","Mesothelioma: Open Targets association 0.69 with malignant mesothelioma (MONDO_0006292)","Myeloproliferative neoplasms: Open Targets association 0.68 with myeloproliferative neoplasm (MONDO_0020076)","Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)","Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/wt1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"wilms-tumor","kind":"cancer","name":"Wilms tumour (nephroblastoma)","route":"/cancers/wilms-tumor/"}],"drug":[{"id":"ino-5401","kind":"drug","name":"INO-5401","route":"/drugs/ino-5401/"}]}}