{"entity":{"id":"wwox","kind":"target","name":"WWOX","aka":["WW domain containing oxidoreductase","WW domain-containing oxidoreductase","WOX1","SDR41C1"],"tldr":"WWOX (WW domain-containing oxidoreductase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer.","summary":"Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis. Required for normal bone development.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes genetic literature 0.30, literature 0.98, genetic association 0.76, somatic mutation 0.55, animal model 0.49).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12799"},{"label":"UniProt Q9NZC7","url":"https://www.uniprot.org/uniprotkb/Q9NZC7/entry"},{"label":"NCBI Gene 51741","url":"https://www.ncbi.nlm.nih.gov/gene/51741"},{"label":"Ensembl ENSG00000186153","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186153"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["esophageal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WWOX","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12799","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12799","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NZC7","url":"https://www.uniprot.org/uniprotkb/Q9NZC7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000186153","url":"https://platform.opentargets.org/target/ENSG00000186153/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: oesophageal cancer 0.62 (GraphQL API, CC0)"}],"hgnc":"HGNC:12799","ensembl":"ENSG00000186153","uniprot":"Q9NZC7","entrez":"51741","biology":"Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signalling and TGFB1-mediated cell death. May also play a role in tumour necrosis factor (TNF)-mediated cell death. Location: Cytoplasm; Nucleus; Mitochondrion; Golgi apparatus (UniProt). Locus 16q23.1-q23.2 (HGNC).","whereFound":["Oesophageal cancer: Open Targets association 0.62 with oesophageal cancer (MONDO_0007576)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/wwox/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}]}}