{"entity":{"id":"wwtr1","kind":"target","name":"WWTR1","aka":["WW domain containing transcription regulator 1","WW domain-containing transcription regulator protein 1","DKFZp586I1419"],"tldr":"WWTR1 (WW domain-containing transcription regulator protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer, Breast cancer and Skin cancer.","summary":"Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes affected pathway 0.25, literature 0.99, genetic association 0.00, somatic mutation 0.98, animal model 0.53). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Ovarian Epithelial Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24042","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24042"},{"label":"UniProt Q9GZV5","url":"https://www.uniprot.org/uniprotkb/Q9GZV5/entry"},{"label":"NCBI Gene 25937","url":"https://www.ncbi.nlm.nih.gov/gene/25937"},{"label":"Ensembl ENSG00000018408","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000018408"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["ovarian","breast-cancer","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"WWTR1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:24042","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24042","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9GZV5","url":"https://www.uniprot.org/uniprotkb/Q9GZV5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000018408","url":"https://platform.opentargets.org/target/ENSG00000018408/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: skin cancer 0.52, breast cancer 0.55 (GraphQL API, CC0)"},{"label":"IntOGen WWTR1","url":"https://www.intogen.org/search?gene=WWTR1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:24042","ensembl":"ENSG00000018408","uniprot":"Q9GZV5","entrez":"25937","biology":"Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. Location: Nucleus; Cytoplasm; Cell membrane; Cell junction, tight junction (UniProt). Locus 3q25.1 (HGNC).","whereFound":["Ovarian cancer: IntOGen driver in 1 cohort (OVT)","Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/wwtr1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}