{"entity":{"id":"xpa","kind":"target","name":"XPA","aka":["XPA, DNA damage recognition and repair factor","DNA repair protein complementing XP-A cells","XP1"],"tldr":"XPA (DNA repair protein complementing XP-A cells) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Colorectal cancer and Basal cell carcinoma.","summary":"Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.\n\nOpen Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes literature 0.94, animal model 0.26, genetic association 0.83, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12814","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12814"},{"label":"UniProt P23025","url":"https://www.uniprot.org/uniprotkb/P23025/entry"},{"label":"NCBI Gene 7507","url":"https://www.ncbi.nlm.nih.gov/gene/7507"},{"label":"Ensembl ENSG00000136936","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136936"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","colorectal","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"XPA","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12814","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12814","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23025","url":"https://www.uniprot.org/uniprotkb/P23025/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136936","url":"https://platform.opentargets.org/target/ENSG00000136936/associations","note":"association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: colorectal cancer 0.51, skin cancer 0.62, basal cell carcinoma 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:12814","ensembl":"ENSG00000136936","uniprot":"P23025","entrez":"7507","biology":"Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3. Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilising the complex in a different conformation than in transcribing TFIIH. Location: Nucleus (UniProt). Locus 9q22.33 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.62 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Basal cell carcinoma: Open Targets association 0.59 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"other","prevalence":[]},"route":"/targets/xpa/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}