{"entity":{"id":"xrcc1","kind":"target","name":"XRCC1","aka":["X-ray repair cross complementing 1","DNA repair protein XRCC1"],"tldr":"XRCC1 (DNA repair protein XRCC1) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer and Non-small-cell lung cancer.","summary":"Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognises and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Docetaxel, Gemcitabine, Carboplatin and Vinorelbine and others. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.78).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12828","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12828"},{"label":"UniProt P18887","url":"https://www.uniprot.org/uniprotkb/P18887/entry"},{"label":"NCBI Gene 7515","url":"https://www.ncbi.nlm.nih.gov/gene/7515"},{"label":"Ensembl ENSG00000073050","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073050"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["cervical","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["base-excision-repair-parp"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword \"DNA repair\". Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"XRCC1","role":["drug-target","biomarker","dna-repair"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:12828","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12828","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P18887","url":"https://www.uniprot.org/uniprotkb/P18887/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene XRCC1","url":"https://civicdb.org/features/6144","note":"3 evidence items, 0 assertions, 2 variants; diseases: Lung Non-small Cell Carcinoma, Cervical Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000073050","url":"https://platform.opentargets.org/target/ENSG00000073050/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"hgnc":"HGNC:12828","ensembl":"ENSG00000073050","uniprot":"P18887","entrez":"7515","biology":"Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognises and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity. Location: Nucleus; Chromosome (UniProt). Locus 19q13.31 (HGNC).","whereFound":["Cervical cancer: CIViC evidence names this disease","Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/xrcc1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"pathway":[{"id":"base-excision-repair-parp","kind":"pathway","name":"Base excision repair, PARP & alkylation damage","route":"/pathways/base-excision-repair-parp/"}]}}