{"entity":{"id":"xrcc2","kind":"target","name":"XRCC2","aka":["X-ray repair cross complementing 2","DNA repair protein XRCC2","FANCU"],"tldr":"XRCC2 (DNA repair protein XRCC2) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment.\n\nOpen Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.87, genetic association 0.74, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12829","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12829"},{"label":"UniProt O43543","url":"https://www.uniprot.org/uniprotkb/O43543/entry"},{"label":"NCBI Gene 7516","url":"https://www.ncbi.nlm.nih.gov/gene/7516"},{"label":"Ensembl ENSG00000196584","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196584"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"XRCC2","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12829","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12829","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43543","url":"https://www.uniprot.org/uniprotkb/O43543/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196584","url":"https://platform.opentargets.org/target/ENSG00000196584/associations","note":"association with cancer (MONDO_0004992) 0.70;  (GraphQL API, CC0)"}],"hgnc":"HGNC:12829","ensembl":"ENSG00000196584","uniprot":"O43543","entrez":"7516","biology":"Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 7q36.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/xrcc2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}