{"entity":{"id":"yap1","kind":"target","name":"YAP1","aka":["Yes1 associated transcriptional regulator","Transcriptional coactivator YAP1","YAP65","YAP-1"],"tldr":"YAP1 (Transcriptional coactivator YAP1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Oesophageal cancer and Breast cancer.","summary":"Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signalling pathway, crucial for organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The Hippo signalling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 2 variants, naming Docetaxel, Verteporfin and Fluorouracil. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes affected pathway 0.27, literature 1.00, genetic association 0.00, somatic mutation 0.97, animal model 0.53).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16262","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16262"},{"label":"UniProt P46937","url":"https://www.uniprot.org/uniprotkb/P46937/entry"},{"label":"NCBI Gene 10413","url":"https://www.ncbi.nlm.nih.gov/gene/10413"},{"label":"Ensembl ENSG00000137693","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137693"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["esophageal","breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"YAP1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:16262","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16262","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P46937","url":"https://www.uniprot.org/uniprotkb/P46937/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene YAP1","url":"https://civicdb.org/features/8292","note":"3 evidence items, 0 assertions, 2 variants; diseases: Oesophageal Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000137693","url":"https://platform.opentargets.org/target/ENSG00000137693/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: breast cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:16262","ensembl":"ENSG00000137693","uniprot":"P46937","entrez":"10413","biology":"Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signalling pathway, crucial for organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The Hippo signalling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes. The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT). Location: Cytoplasm; Nucleus; Cell junction, tight junction; Cell membrane (UniProt). Locus 11q22.1 (HGNC).","whereFound":["Oesophageal cancer: CIViC evidence names this disease","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/yap1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}]}}