{"entity":{"id":"ylst","kind":"trial","name":"YLST","aka":["Yorkshire Lung Screening Trial","ISRCTN42704678"],"tldr":"The Leeds trial that answered the operational questions a national screening programme actually has to answer: who responds, which risk rule to use, what it costs, and whether stopping smoking can be built into the same appointment.","summary":"The Yorkshire Lung Screening Trial invited 44,943 people; 50.8 percent responded, with response significantly lower among current smokers (adjusted odds ratio 0.44) and in the most deprived fifth (0.58). Of responders, 34.4 percent were eligible and offered a lung health check, 86.8 percent attended and 99.7 percent of those eligible had a baseline scan.\n\nIts most consequential result compared the three eligibility rules a programme might use. Of responders, the PLCOm2012 model at a six-year risk of 1.51 percent made 28.0 percent eligible and captured 91.1 percent of all the cancers; the Liverpool Lung Project model version 2 at 5 percent made 20.5 percent eligible and captured 77.0 percent; the 2013 United States Preventive Services Task Force criteria made 18.9 percent eligible and captured 62.8 percent. Even at equal numbers screened the risk models beat the categorical rule. Cost-effectiveness was comfortable for all three, from 3,797 to 4,013 pounds per quality-adjusted life-year. A stop-smoking practitioner co-located with the scanner was accepted by 89 percent of eligible smokers, and 12.4 percent were carbon-monoxide-validated quitters at four weeks. Adherence to the second round was 86.8 percent.","status":"positive","asOf":"2026-09-25","links":[{"label":"European Respiratory Journal 2022 (participation)","url":"https://europepmc.org/article/MED/35777775"},{"label":"Journal of Thoracic Oncology 2025 (eligibility)","url":"https://europepmc.org/article/MED/39709114"},{"label":"European Respiratory Journal 2024 (stop-smoking service)","url":"https://europepmc.org/article/MED/38636970"},{"label":"ISRCTN42704678","url":"https://www.isrctn.com/ISRCTN42704678"}],"tags":["uk","screening","lung"],"related":[],"cancers":["nsclc","lung-cancer"],"sections":["early-detection","prevention"],"technologies":["low-dose-ct-screening","smoking-cessation-after-diagnosis"],"targets":[],"drugs":[],"companies":[],"institutions":["leeds-cancer-centre"],"pathways":[],"terms":[],"trials":["ukls"],"people":["matthew-callister","philip-crosbie"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"ISRCTN42704678","phase":"3","setting":"Community lung health checks delivered from mobile CT vans to ever-smokers aged 55 to 80 registered with a Leeds GP, with a single-consent Zelen design and household randomisation; two screening rounds two years apart, recruiting September 2018 to October 2024","sponsor":"University of Leeds, funded by Yorkshire Cancer Research","result":"PLCOm2012 at 1.51 percent detected 91.1 percent of cancers against 62.8 percent for the 2013 USPSTF rule; incremental cost-effectiveness 3,797 to 4,013 pounds per quality-adjusted life-year; 12.4 percent validated quit rate from the co-located stop-smoking service.","yearReported":2025,"enrolled":8847,"enrolledBasis":"registered","enrolledNote":"8,847 were enrolled against a target of 6,892; 44,943 people were invited to reach them.","outcomes":[]},"route":"/trials/ylst/","neighbours":{"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"},{"id":"prevention","kind":"section","name":"Prevention & Risk","route":"/fronts/prevention/"}],"technology":[{"id":"low-dose-ct-screening","kind":"technology","name":"Low-dose CT lung screening","route":"/technologies/low-dose-ct-screening/"},{"id":"smoking-cessation-after-diagnosis","kind":"technology","name":"Smoking cessation in cancer patients","route":"/technologies/smoking-cessation-after-diagnosis/"}],"institution":[{"id":"leeds-cancer-centre","kind":"institution","name":"Leeds Cancer Centre, St James's University Hospital","route":"/institutions/leeds-cancer-centre/"}],"trial":[{"id":"summit-lung","kind":"trial","name":"SUMMIT (lung health check study)","route":"/trials/summit-lung/"},{"id":"ukls","kind":"trial","name":"UKLS","route":"/trials/ukls/"}],"person":[{"id":"matthew-callister","kind":"person","name":"Matthew Callister","route":"/people/matthew-callister/"},{"id":"philip-crosbie","kind":"person","name":"Philip Crosbie","route":"/people/philip-crosbie/"}]}}