{"entity":{"id":"ywhae","kind":"target","name":"YWHAE","aka":["tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon","14-3-3 protein epsilon","FLJ45465"],"tldr":"YWHAE (14-3-3 protein epsilon) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.","summary":"Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.00, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:12851","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12851"},{"label":"UniProt P62258","url":"https://www.uniprot.org/uniprotkb/P62258/entry"},{"label":"NCBI Gene 7531","url":"https://www.ncbi.nlm.nih.gov/gene/7531"},{"label":"Ensembl ENSG00000108953","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108953"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"YWHAE","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:12851","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12851","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P62258","url":"https://www.uniprot.org/uniprotkb/P62258/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000108953","url":"https://platform.opentargets.org/target/ENSG00000108953/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: sarcoma 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:12851","ensembl":"ENSG00000108953","uniprot":"P62258","entrez":"7531","biology":"Adapter protein implicated in the regulation of a large spectrum of both general and specialised signalling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Plays a positive role in the antiviral signalling pathway upstream of TBK1 via interaction with RIGI. Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signalling during viral infection. Location: Nucleus; Cytoplasm; Melanosome (UniProt). Locus 17p13.3 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)"],"targetClass":"other","prevalence":[]},"route":"/targets/ywhae/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}