{"entity":{"id":"zbtb10","kind":"target","name":"ZBTB10","aka":["zinc finger and BTB domain containing 10","Zinc finger and BTB domain-containing protein 10","RINZF","FLJ12752"],"tldr":"ZBTB10 (Zinc finger and BTB domain-containing protein 10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Basal cell carcinoma.","summary":"May be involved in transcriptional regulation.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.88, animal model 0.52, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30953","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30953"},{"label":"UniProt Q96DT7","url":"https://www.uniprot.org/uniprotkb/Q96DT7/entry"},{"label":"NCBI Gene 65986","url":"https://www.ncbi.nlm.nih.gov/gene/65986"},{"label":"Ensembl ENSG00000205189","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000205189"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZBTB10","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:30953","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30953","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96DT7","url":"https://www.uniprot.org/uniprotkb/Q96DT7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000205189","url":"https://platform.opentargets.org/target/ENSG00000205189/associations","note":"association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: basal cell carcinoma 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:30953","ensembl":"ENSG00000205189","uniprot":"Q96DT7","entrez":"65986","biology":"May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).","whereFound":["Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/zbtb10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"}]}}