{"entity":{"id":"zbtb20","kind":"target","name":"ZBTB20","aka":["zinc finger and BTB domain containing 20","Zinc finger and BTB domain-containing protein 20","ODA-8S","DKFZp566F123","ZNF288"],"tldr":"ZBTB20 (Zinc finger and BTB domain-containing protein 20) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts.","summary":"May be a transcription factor that may be involved in haematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Low-Grade Glioma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13503","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13503"},{"label":"UniProt Q9HC78","url":"https://www.uniprot.org/uniprotkb/Q9HC78/entry"},{"label":"NCBI Gene 26137","url":"https://www.ncbi.nlm.nih.gov/gene/26137"},{"label":"Ensembl ENSG00000181722","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181722"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZBTB20","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:13503","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13503","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HC78","url":"https://www.uniprot.org/uniprotkb/Q9HC78/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZBTB20","url":"https://www.intogen.org/search?gene=ZBTB20","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13503","ensembl":"ENSG00000181722","uniprot":"Q9HC78","entrez":"26137","biology":"May be a transcription factor that may be involved in haematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal. Location: Nucleus (UniProt). Locus 3q13.31 (HGNC).","whereFound":[],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/zbtb20/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}]}}