{"entity":{"id":"zbtb48","kind":"target","name":"ZBTB48","aka":["zinc finger and BTB domain containing 48","Zinc finger and BTB domain-containing protein 48","ZNF855","HKR3"],"tldr":"ZBTB48 (Zinc finger and BTB domain-containing protein 48) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.","summary":"Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Angiosarcoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4930","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4930"},{"label":"UniProt P10074","url":"https://www.uniprot.org/uniprotkb/P10074/entry"},{"label":"NCBI Gene 3104","url":"https://www.ncbi.nlm.nih.gov/gene/3104"},{"label":"Ensembl ENSG00000204859","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204859"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["angiosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZBTB48","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:4930","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4930","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10074","url":"https://www.uniprot.org/uniprotkb/P10074/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZBTB48","url":"https://www.intogen.org/search?gene=ZBTB48","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:4930","ensembl":"ENSG00000204859","uniprot":"P10074","entrez":"3104","biology":"Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Location: Nucleus; Chromosome, telomere (UniProt). Locus 1p36.31 (HGNC).","whereFound":["Angiosarcoma: IntOGen driver in 1 cohort (ANGS)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/zbtb48/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"angiosarcoma","kind":"cancer","name":"Angiosarcoma","route":"/cancers/angiosarcoma/"}]}}