{"entity":{"id":"zbtb7b","kind":"target","name":"ZBTB7B","aka":["zinc finger and BTB domain containing 7B","Zinc finger and BTB domain-containing protein 7B","ZBTB15","c-Krox","hcKrox","ZNF857B","vGAF","ThPOK","ZFP67"],"tldr":"ZBTB7B (Zinc finger and BTB domain-containing protein 7B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.","summary":"Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18668","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18668"},{"label":"UniProt O15156","url":"https://www.uniprot.org/uniprotkb/O15156/entry"},{"label":"NCBI Gene 51043","url":"https://www.ncbi.nlm.nih.gov/gene/51043"},{"label":"Ensembl ENSG00000160685","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160685"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["uterine-carcinosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZBTB7B","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18668","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18668","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15156","url":"https://www.uniprot.org/uniprotkb/O15156/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZBTB7B","url":"https://www.intogen.org/search?gene=ZBTB7B","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18668","ensembl":"ENSG00000160685","uniprot":"O15156","entrez":"51043","biology":"Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signalling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. Location: Nucleus (UniProt). Locus 1q21.3 (HGNC).","whereFound":["Uterine carcinosarcoma: IntOGen driver in 1 cohort (UCS)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/zbtb7b/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"uterine-carcinosarcoma","kind":"cancer","name":"Uterine carcinosarcoma","route":"/cancers/uterine-carcinosarcoma/"}]}}