{"entity":{"id":"zc3hav1","kind":"target","name":"ZC3HAV1","aka":["zinc finger CCCH-type containing, antiviral 1","Zinc finger CCCH-type antiviral protein 1","FLB6421","FLJ13288","MGC48898","ZC3HDC2","ZC3H2","PARP13","ARTD13"],"tldr":"ZC3HAV1 (Zinc finger CCCH-type antiviral protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.64, affected pathway 0.89, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23721","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23721"},{"label":"UniProt Q7Z2W4","url":"https://www.uniprot.org/uniprotkb/Q7Z2W4/entry"},{"label":"NCBI Gene 56829","url":"https://www.ncbi.nlm.nih.gov/gene/56829"},{"label":"Ensembl ENSG00000105939","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105939"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZC3HAV1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23721","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23721","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z2W4","url":"https://www.uniprot.org/uniprotkb/Q7Z2W4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000105939","url":"https://platform.opentargets.org/target/ENSG00000105939/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:23721","ensembl":"ENSG00000105939","uniprot":"Q7Z2W4","entrez":"56829","biology":"Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae, including human immunodeficiency virus type 1, filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Exhibits stronger antiviral activity than isoform 2 against MuLV expression and Semliki forest virus infection. Location: Nucleus; Lysosome; Late endosome; Cytoplasm (UniProt). Locus 7q34 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/zc3hav1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}