{"entity":{"id":"zcchc8","kind":"target","name":"ZCCHC8","aka":["zinc finger CCHC-type containing 8","Zinc finger CCHC domain-containing protein 8","DKFZp434E2220"],"tldr":"ZCCHC8 (Zinc finger CCHC domain-containing protein 8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.","summary":"Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Stomach Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25265","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25265"},{"label":"UniProt Q6NZY4","url":"https://www.uniprot.org/uniprotkb/Q6NZY4/entry"},{"label":"NCBI Gene 55596","url":"https://www.ncbi.nlm.nih.gov/gene/55596"},{"label":"Ensembl ENSG00000033030","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000033030"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZCCHC8","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:25265","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25265","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6NZY4","url":"https://www.uniprot.org/uniprotkb/Q6NZY4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZCCHC8","url":"https://www.intogen.org/search?gene=ZCCHC8","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:25265","ensembl":"ENSG00000033030","uniprot":"Q6NZY4","entrez":"55596","biology":"Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. May be involved in pre-mRNA splicing. It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function. Location: Nucleus, nucleoplasm; Nucleus (UniProt). Locus 12q24.31 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/zcchc8/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}