{"entity":{"id":"zcrb1","kind":"target","name":"ZCRB1","aka":["zinc finger CCHC-type and RNA binding motif containing 1","Zinc finger CCHC-type and RNA-binding motif-containing protein 1","MADP-1","MADP1","RBM36","ZCCHC19","SNRNP31"],"tldr":"ZCRB1 (Zinc finger CCHC-type and RNA-binding motif-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.","summary":"UniProt has no function text for Q8TBF4; HGNC names it \"zinc finger CCHC-type and RNA binding motif containing 1\".\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29620","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29620"},{"label":"UniProt Q8TBF4","url":"https://www.uniprot.org/uniprotkb/Q8TBF4/entry"},{"label":"NCBI Gene 85437","url":"https://www.ncbi.nlm.nih.gov/gene/85437"},{"label":"Ensembl ENSG00000139168","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139168"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZCRB1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29620","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29620","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8TBF4","url":"https://www.uniprot.org/uniprotkb/Q8TBF4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ZCRB1","url":"https://www.intogen.org/search?gene=ZCRB1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29620","ensembl":"ENSG00000139168","uniprot":"Q8TBF4","entrez":"85437","biology":"UniProt has no function text for Q8TBF4; HGNC names it \"zinc finger CCHC-type and RNA binding motif containing 1\". Location: Nucleus, nucleoplasm (UniProt). Locus 12q12 (HGNC).","whereFound":["Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/zcrb1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"}]}}