{"entity":{"id":"zeb1","kind":"target","name":"ZEB1","aka":["zinc finger E-box binding homeobox 1","Zinc finger E-box-binding homeobox 1","AREB6","NIL-2-A","Zfhep","Zfhx1a","FECD6","TCF8","PPCD3"],"tldr":"ZEB1 (Zinc finger E-box-binding homeobox 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Nasopharyngeal carcinoma, Multiple myeloma and 4 more.","summary":"Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type.\n\nCIViC holds 9 clinical evidence items and 0 assertions across 3 variants, naming Doxorubicin, Salinomycin, Gemcitabine and Cytarabine and others. IntOGen calls it a driver in 6 cohorts (5 activating, 1 loss-of-function), covering Glioblastoma Multiforme, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Nasopharyngeal Carcinoma, Plasma Cell Myeloma, Small Cell Lung Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11642","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11642"},{"label":"UniProt P37275","url":"https://www.uniprot.org/uniprotkb/P37275/entry"},{"label":"NCBI Gene 6935","url":"https://www.ncbi.nlm.nih.gov/gene/6935"},{"label":"Ensembl ENSG00000148516","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000148516"}],"tags":["cancer-genes-wave"],"related":["civic","intogen"],"cancers":["colorectal","nasopharyngeal","multiple-myeloma","mantle-cell-lymphoma","nsclc","glioblastoma","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["emt","invasion-ecm-degradation"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 7 therapies; IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 9 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZEB1","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11642","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11642","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P37275","url":"https://www.uniprot.org/uniprotkb/P37275/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ZEB1","url":"https://civicdb.org/features/5649","note":"9 evidence items, 0 assertions, 3 variants; diseases: Mantle Cell Lymphoma, Colon Cancer, Cancer (GraphQL API, CC0)"},{"label":"IntOGen ZEB1","url":"https://www.intogen.org/search?gene=ZEB1","note":"driver in 6 cohorts (Act 5, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11642","ensembl":"ENSG00000148516","uniprot":"P37275","entrez":"6935","biology":"Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Location: Nucleus (UniProt). Locus 10p11.22 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease","Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Mantle cell lymphoma: CIViC evidence names this disease","Non-small-cell lung cancer: IntOGen driver in 2 cohorts (LUAD, LUSC)","Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/zeb1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"mantle-cell-lymphoma","kind":"cancer","name":"Mantle cell lymphoma","route":"/cancers/mantle-cell-lymphoma/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"pathway":[{"id":"emt","kind":"pathway","name":"Epithelial-mesenchymal transition & drug efflux","route":"/pathways/emt/"},{"id":"invasion-ecm-degradation","kind":"pathway","name":"Invasion: proteases, adhesion & the invasive front","route":"/pathways/invasion-ecm-degradation/"}]}}